Recent advance in mechanism of advanced glycation end-product receptors in pathological pain / 中华神经医学杂志

ABSTRACT

The advanced glycation end-products (RAGE) receptors are a kind of new pattern-recognition receptors, which express in both immune cells and nerve cells. New studies have shown that aberrant activation of RAGE involves in pathological pain, and inhibiting the activation of RAGE can prevent or alleviate pathological pain in animals. In this paper, we review the recent literatures in the involvement of RAGE in pathological pain, and discuss the possibility and challenges of RAGE as a therapeutic target for pathological pain.