Efficacy of traditional Chinese medicine compound on amenorrhea in female patients with schizophrenia caused by antipsychotic drugs： a Meta-analysis / 四川精神卫生

ABSTRACT

BackgroundThe incidence of mental disorders is steadily increasing. However， antipsychotic medications， commonly used in treatment， can lead to drug-induced amenorrhea in female patients. This side effect significantly reduces medication adherence and increases the risk of disease recurrence. Therefore， addressing drug-induced amenorrhea in female patients has become an urgent problem requiring effective solutions. ObjectiveTo explore the efficacy and safety of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea， so as to provide guidance for the treatment of this condition using traditional Chinese medicine compound. MethodsOn September 4， 2022， a computerized search was conducted on across multiple databases， including China National Knowledge Infrastructure， VIP Database， Wanfang Database， China Biomedical Literature Database， PubMed， Cochrane Library and Embase， and randomized controlled trials （RCT） of traditional Chinese medicine compound in treating antipsychotic-induced amenorrhea were collected. The quality of the included literature was assessed using Cochrane 5.3 bias risk assessment tool. Meta-analysis was performed to assess the total effective rate， cure rate， incidence of adverse reactions and recurrence rate using RevMan 5.3. ResultsUltimately， 22 RCT involving 1 879 patients were included. Meta-analysis results showed that the total effective rate （RR=1.29， 95% CI： 1.16~1.44） and cure rate （RR=1.62， 95% CI： 1.45~1.80） of traditional Chinese medicine compound or its combination with western medicine in treating antipsychotic-induced amenorrhea were significantly higher compared to western medicine alone. Moreover， the incidence of adverse reactions （RR=0.56， 95% CI： 0.41~0.76） and recurrence rate （RR=0.16， 95% CI： 0.06~0.42） were significantly lower than those of western medicine alone. ConclusionTraditional Chinese medicine compound may offer benefits in ameliorating antipsychotic-induced amenorrhea and its safety is better than simple western medicine treatment.