Levels of serum Pannexin1 in patients with acute ischemic stroke and its association with severity and prognosis / 中风与神经疾病杂志

ABSTRACT

@#ObjectiveTo explore the expression of Pannexin1 in patients with acute ischemic stroke（AIS）and its association with severity and prognosis. MethodsA total of 113 patients with AIS admitted to our hospital from January 2017 to January 2020 were selected as case group，who were divided into mild impairment group（NIHSS<4 points，n=42），moderate impairment group（NIHSS 4～15 points，n=45），severe impairment group（NIHSS>15 pointe，n=26）according to the degree of neurological impairment. Also，the patients were divided into small infarction group（infarction volume<5 cm3，n=37），moderate infarction group（infarction volume 5～10cm3，n=51）and large infarction group（infarction volume>10cm3，n=25）according to the volume of cerebral infarction. 90 days after treatment，the patients were divided into good prognosis group（mRS<=2 points，n=81）and poor prognosis group（mRS 3～5 points，n=32）according to the modified Rankin Scale（mRS）. At the same time，58 healthy volunteers were randomly selected as control group. The Pannexin1 level were detected by enzyme-linked immunosorbent assay. ResultsThe level of Pannexin1 in case group was higher than that in control group（P<0.05）. With the aggravation of neurological impairment and the increase of cerebral infarction volume，the level of Pannexin1 in AIS patients increased gradually（P<0.05）. The level of Pannexin1 in good prognosis group was lower than that in bad prognosis group（P<0.05）. The Pearson’s product moment correlation analysis showed that Pannexin1 was positively associated with NIHSS score，infarct volume and mRS score（r=0.632，0.598，0.671；P<0.05）. The AUC of Pannexin1 in predicting poor prognosis was 0.865，the sensitivity and specificity were 87.50% and 86.42% respectively. ConclusionSerum Pannexin1 highly express in patients with AIS，which is closely related to the severity of the disease and prognosis. Early detection of Pannexin1 can be used as a biochemical index to judge the severity of disease and predict poor prognosis.