Cytotoxicity of gamma-ray in rat immature hippocampal neurons
Journal of Veterinary Science
; : 203-207, 2011.
Article
在 En
| WPRIM
| ID: wpr-108033
Responsible library:
WPRO
ABSTRACT
This in vitro study evaluated the detrimental effect of acute gamma (gamma)-irradiation on rat immature hippocampal neurons. Rat immature hippocampal neurons (0.5 day in vitro) were irradiated with 0~4 Gy gamma-rays. Cytotoxicity was analyzed using a lactate dehydrogenase release assay at 24 h after gamma-irradiation. Radiation-induced cytotoxicity in immature hippocampal neurons increased in a dose-dependent manner. Pre-treatments of pro-apoptotic caspase inhibitors and anti-oxidative substances significantly blocked gamma-irradiation-induced cytotoxicity in immature hippocampal neurons. The results suggest that the caspase-dependent cytotoxicity of gamma-rays in immature hippocampal cultured neurons may be caused by oxidative stress.
Key words
全文:
1
索引:
WPRIM
主要主题:
Catechin
/
Cell Survival
/
Cells, Cultured
/
Poly(ADP-ribose) Polymerases
/
Rats, Sprague-Dawley
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Amifostine
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Dose-Response Relationship, Radiation
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Caspase 3
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Gamma Rays
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Hippocampus
限制:
Animals
/
Pregnancy
语言:
En
期刊:
Journal of Veterinary Science
年:
2011
类型:
Article