MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
Experimental & Molecular Medicine
; : e156-2015.
Article
在 En
| WPRIM
| ID: wpr-147138
Responsible library:
WPRO
ABSTRACT
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6 production by macrophages in response to LPS has remained unclear, however. We now show that LPS induces IL-6 synthesis in mouse peritoneal macrophages via the leukotriene B4 receptor BLT2. Our results suggest that TLR4-MyD88 signaling functions upstream of BLT2 and that the generation of reactive oxygen species (ROS) by NADPH oxidase 1 (Nox1) and consequent activation of the transcription factor nuclear factor (NF)-kappaB function downstream of BLT2 in this response. These results suggest that a TLR4-MyD88-BLT2-Nox1-ROS-NF-kappaB pathway contributes to the synthesis of IL-6 in LPS-stimulated mouse macrophages.
全文:
1
索引:
WPRIM
主要主题:
Signal Transduction
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Cell Line
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Lipopolysaccharides
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NF-kappa B
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Interleukin-6
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Reactive Oxygen Species
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Receptors, Leukotriene B4
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Macrophages, Peritoneal
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Leukotriene B4
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Myeloid Differentiation Factor 88
限制:
Animals
语言:
En
期刊:
Experimental & Molecular Medicine
年:
2015
类型:
Article