Investigation of the Bovine Leukemia Virus Proviral DNA in Human Leukemias and Lung cancers in Korea
Journal of Korean Medical Science
; : 603-606, 2005.
Article
在 En
| WPRIM
| ID: wpr-147619
Responsible library:
WPRO
ABSTRACT
The bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. This study investigated the presence of the BLV in leukemia (179 acute lymphoblastic leukemia, 292 acute myeloid leukemia and 46 chronic myelogenous leukemia cases) and 162 lung cancer patients (139 adenocarcinoma, 23 squamous cell carcinoma) to determine if the BLV is a causative organism of leukemia and lung cancer in Koreans. A BLV infection was confirmed in human cells by PCR using a BLV-8 primer combination. All 517 cases of human leukemia and 162 lung cancer were negative for a PCR of the BLV proviral DNA. In conclusion, although meat has been imported from BLV endemic areas, the BLV infection does not appear to be the cause of human leukemia or lung cancer in Koreans. These results can be used as a control for further studies on the BLV in Koreans.
Key words
全文:
1
索引:
WPRIM
主要主题:
DNA, Viral
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Adenocarcinoma
/
Leukemia
/
Leukemia, Myeloid
/
Cell Line
/
Polymerase Chain Reaction
/
Acute Disease
/
Proviruses
/
Leukemia Virus, Bovine
限制:
Humans
国家/地区名称主题:
Asia
语言:
En
期刊:
Journal of Korean Medical Science
年:
2005
类型:
Article