Lung Cancer Risk and Residential Exposure to Air Pollution: A Korean Population-Based Case-Control Study
Yonsei Medical Journal
; : 1111-1118, 2017.
Article
在 En
| WPRIM
| ID: wpr-15483
Responsible library:
WPRO
ABSTRACT
PURPOSE: To investigate the association between long-term exposure to ambient air pollution and lung cancer incidence in Koreans. MATERIALS AND METHODS: This was a population-based case-control study covering 908 lung cancer patients and 908 controls selected from a random sample of people within each Korean province and matched according to age, sex, and smoking status. We developed land-use regression models to estimate annual residential exposure to particulate matter (PM₁₀) and nitrogen dioxide (NO₂) over a 20-year exposure period. Logistic regression was used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CI). RESULTS: Increases in lung cancer incidence (expressed as adjusted OR) were 1.09 (95% CI: 0.96−1.23) with a ten-unit increase in PM₁₀ (µg/m³) and 1.10 (95% CI: 1.00−1.22) with a ten-unit increase in NO₂ (ppb). Tendencies for stronger associations between air pollution and lung cancer incidence were noted among never smokers, among those with low fruit consumption, and among those with a higher education level. Air pollution was more strongly associated with squamous cell and small cell carcinomas than with adenocarcinoma of the lung. CONCLUSION: This study provides evidence that PM₁₀ and NO₂ contribute to lung cancer incidence in Korea.
Key words
全文:
1
索引:
WPRIM
主要主题:
Smoke
/
Adenocarcinoma
/
Smoking
/
Case-Control Studies
/
Logistic Models
/
Odds Ratio
/
Incidence
/
Carcinoma, Small Cell
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Air Pollution
/
Education
研究类型:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
限制:
Humans
国家/地区名称主题:
Asia
语言:
En
期刊:
Yonsei Medical Journal
年:
2017
类型:
Article