Myeloid Sarcoma in Patients with RUNX1/RUNX1T1 Positive AML and a c-kit Mutation / 대한내과학회지
Korean Journal of Medicine
; : 517-525, 2011.
Article
在 Ko
| WPRIM
| ID: wpr-164061
Responsible library:
WPRO
ABSTRACT
t (8;21)(q22;q22) is the most frequently detected cytogenetic abnormality in patients with acute myeloid leukemia (AML) and accounts for 8-21% of de novo AML. The translocation involves two genes, RUNX1 (formerly AML1) on 21q22 and RUNX1T1 (ETO) on 8q22. RUNX1/RUNX1T1 translocation confers a favorable prognosis, but a subset of patients has a precipitous course with a high incidence of relapse. This patient subset is associated with the presence of a c-kit mutation. c-kit is a proto-oncogene, which encodes a type III transmembrane tyrosine kinase, which elicits a variety of cellular responses essential for the development of bone marrow stem cells. The expression of the c-kit mutation in AML is < 2%, whereas AML with RUNX1/RUNX1T1 shows higher rates of c-kit mutation and is associated with extramedullary leukemia and poor clinical outcome. We report cases of myeloid sarcoma in patients with RUNX1/RUNX1T1-positive AML and a c-kit mutation.
Key words
全文:
1
索引:
WPRIM
主要主题:
Prognosis
/
Recurrence
/
Stem Cells
/
Bone Marrow
/
Protein-Tyrosine Kinases
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Proto-Oncogenes
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Leukemia, Myeloid, Acute
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Leukemia
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Oncogene Proteins, Fusion
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Incidence
研究类型:
Incidence_studies
/
Prognostic_studies
限制:
Humans
语言:
Ko
期刊:
Korean Journal of Medicine
年:
2011
类型:
Article