Efficacy of the Mineral Oil and Hyaluronic Acid Mixture Eye Drops in Murine Dry Eye
Korean Journal of Ophthalmology
; : 131-137, 2015.
Article
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| WPRIM
| ID: wpr-170373
Responsible library:
WPRO
ABSTRACT
PURPOSE:
To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).METHODS:
Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining.RESULTS:
There was no significant difference in the tear volume between desiccating stress-induced groups. The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group.CONCLUSIONS:
The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity, the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.Key words
全文:
1
索引:
WPRIM
主要主题:
Ophthalmic Solutions
/
Tears
/
Mineral Oil
/
Dry Eye Syndromes
/
Conjunctiva
/
Cornea
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Goblet Cells
/
Disease Models, Animal
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Drug Combinations
/
Emollients
研究类型:
Prognostic_studies
限制:
Animals
语言:
En
期刊:
Korean Journal of Ophthalmology
年:
2015
类型:
Article