The prognostic value of NT-proBNP, Troponin I, and hs-CRP in patients with acute coronary syndrome / 대한내과학회지
Korean Journal of Medicine
; : 200-210, 2009.
Article
在 Ko
| WPRIM
| ID: wpr-17468
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS:
Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), troponin I, and high-sensitivity C-reactive protein (hs-CRP) are each associated with higher rates of death and recurrent myocardial ischemia in patients with acute coronary syndrome (ACS). We evaluated the prognostic value of NT-proBNP and a multi-marker risk approach with the simultaneous assessment of NT-proBNP, troponin I, and hs-CRP in patients with ACS.METHODS:
We included 277 patients who were admitted for ACS between January and December 2006. We measured NT-proBNP, troponin I, and hs-CRP within 24 hours of the onset of symptoms. Patients were followed for a median of 559 days for cardiovascular events, including death, new myocardial infarction, heart failure, or rehospitalization for ACS.RESULTS:
NT-proBNP was the most powerful predictor of clinical outcome among the biomarkers (HR 3.65, 95% CI 2.11-6.30), followed by the peak troponin I and hs-CRP (HR 2.08, 95% CI 1.12-3.87;HR 1.99, 95% CI 1.18-3.37, respectively), but not the baseline troponin I. A multi-marker risk approach with the simultaneous assessment of NT-proBNP, hs-CRP, and peak troponin I was significantly associated with cardiovascular events, especially the presence of three positive biomarkers (adjusted HR 4.20, 95% CI 1.39-12.67).CONCLUSIONS:
NT-proBNP is the most powerful, independent predictor of clinical outcome among the cardiac biomarkers. Since the peak troponin I level provides more prognostic information than the baseline level, follow-up measurement of troponin I may be warranted for risk stratification. The multi-marker risk approach appears to have better prognostic performance than any marker in isolation.Key words
全文:
1
索引:
WPRIM
主要主题:
Peptide Fragments
/
Prognosis
/
Troponin
/
C-Reactive Protein
/
Biomarkers
/
Follow-Up Studies
/
Myocardial Ischemia
/
Troponin I
/
Natriuretic Peptide, Brain
/
Acute Coronary Syndrome
研究类型:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
限制:
Humans
语言:
Ko
期刊:
Korean Journal of Medicine
年:
2009
类型:
Article