Clinical and Angiographic Predictors of Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction
Yonsei Medical Journal
; : 1235-1243, 2015.
Article
在 En
| WPRIM
| ID: wpr-185898
Responsible library:
WPRO
ABSTRACT
PURPOSE: We aimed to discover clinical and angiographic predictors of microvascular dysfunction using the index of microcirculatory resistance (IMR) in patients with ST-segment elevation myocardial infarction (STEMI). MATERIALS AND METHODS: We enrolled 113 patients with STEMI (age, 56+/-11 years; 95 men) who underwent primary percutaneous coronary intervention (PCI). The IMR was measured with a pressure sensor/thermistor-tipped guidewire after primary PCI. The patients were divided into three groups based on IMR values: Low IMR [31 U (48.1+/-17.1 U), n=37]. RESULTS: The age of the Low IMR group was significantly lower than that of the Mid and High IMR groups. The door-to-balloon time was <90 minutes in all patients, and it was not significantly different between groups. Meanwhile, the symptom-onset-to-balloon time was significantly longer in the High IMR group, compared to the Mid and Low IMR groups (p<0.001). In the high IMR group, the culprit lesion was found in a proximal location significantly more often than in a non-proximal location (p=0.008). In multivariate regression analysis, age and symptom-onset-to-balloon time were independent determinants of a high IMR (p=0.013 and p=0.003, respectively). CONCLUSION: Our data suggest that age and symptom-onset-to-balloon time might be the major predictors of microvascular dysfunction in STEMI patients with a door-to-balloon time of <90 minutes.
Key words
全文:
1
索引:
WPRIM
主要主题:
Angiography
/
Regression Analysis
/
Percutaneous Coronary Intervention
/
Operative Time
/
Microcirculation
/
Myocardial Infarction
研究类型:
Diagnostic_studies
/
Prognostic_studies
限制:
Aged
/
Female
/
Humans
/
Male
语言:
En
期刊:
Yonsei Medical Journal
年:
2015
类型:
Article