Comparison of Photocoagulation With Combined Intravitreal Triamcinolone for Diabetic Macular Edema
Korean Journal of Ophthalmology
; : 153-158, 2009.
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| ID: wpr-210152
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ABSTRACT
PURPOSE:
To compare the efficacy between macular laser grid (MLG) photocoagulation and MLG plus intravitreal triamcinolone acetonide (IVTA; MLG+IVTA) therapy in diabetic macular edema (DME) patients.METHODS:
A prospective, randomized, clinical trial was conducted of DME patients. A total of 60 eyes (54 patients) affected by DME were observed for a minimum of 6 months. Thirty eyes of 28 patients who received MLG treatment and 30 eyes of 26 patients who received the combined MLG+IVTA treatment were included in the study. Main outcome measures were BCVA and central macular thickness (CMT) as measured by optical coherence tomography (OCT) at 1, 3, and 6 months after treatment. Additionally, the authors examined retrospectively 20 eyes of 20 patients who were treated with only IVTA and compared with the 2 groups (MLG group and MLG+IVTA group).RESULTS:
Baseline BCVA was 0.53+/-0.32 and CMT was 513.9+/-55.1 microm in the MLG group. At 1 and 3 months after treatment, the MLG group showed no significant improvement of BCVA and CMT, although there was significant improvement after 6 months. In the MLG+IVTA group, the baseline BCVA was 0.59+/-0.29 and CMT was 498.2+/-19.8 microm. After treatment, significant improvement of BCVA and CMT was observed at all follow-up time periods. When comparing the MLG group with the MLG+IVTA group, the latter had better results after 1 and 3 months, although at 6 months, there was no significant difference of BCVA and CMT between the 2 groups. Additionally, the IVTA group showed more improvement than the MLG group at 1 and 3 months but showed no significant difference at 6 months. In addition, the IVTA group showed no significant difference with the MLG+IVTA group at all follow-up time periods.CONCLUSIONS:
For DME patients, the combined MLG+IVTA treatment had a better therapeutic effect than the MLG treatment for improving BCVA and CMT at the early follow-up time periods. IVTA treatment alone could be an additional alternative therapeutic option to combined therapy.Key words
全文:
1
索引:
WPRIM
主要主题:
Postoperative Period
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Vitreous Body
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Triamcinolone Acetonide
/
Visual Acuity
/
Macular Edema
/
Follow-Up Studies
/
Laser Coagulation
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Tomography, Optical Coherence
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Diabetic Retinopathy
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Glucocorticoids
研究类型:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
限制:
Aged
/
Humans
语言:
En
期刊:
Korean Journal of Ophthalmology
年:
2009
类型:
Article