The Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test
Gut and Liver
; : 641-648, 2015.
Article
在 En
| WPRIM
| ID: wpr-216105
Responsible library:
WPRO
ABSTRACT
BACKGROUND/AIMS: M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS: Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospitals in the capital province of Korea. The iM2-PK value was compared with the immunochromatographic fecal occult blood test (iFOBT) and fecal tumor M2-PK enzyme-linked immunosorbent assay (ELISA). RESULTS: A total of 323 subjects were enrolled. The sensitivity of iM2-PK for CRC was 92.8%, which was superior to iFOBT (47.5%, p<0.0001). For adenomatous lesions, the sensitivity of iM2-PK was 69.4%, which was also superior to iFOBT (12.1%, p<0.001). Compared with M2-PK ELISA, iM2-PK exhibited significantly enhanced sensitivity for CRC (97.5% vs 80.0%, p=0.0289). The sensitivity of iM2-PK was higher in advanced stages of CRC compared with cancers confined to the mucosa and submucosa (p<0.05). However, lymph node metastasis had no influence on the sensitivity of iM2-PK. CONCLUSIONS: The iM2-PK exhibited increased sensitivity for identifying CRC and adenomatous lesions compared with iFOBT. Given its rapid results and convenience, CRC screening using iM2-PK is promising.
Key words
全文:
1
索引:
WPRIM
主要主题:
Precancerous Conditions
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Pyruvate Kinase
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Reagent Kits, Diagnostic
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Enzyme-Linked Immunosorbent Assay
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Colorectal Neoplasms
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Biomarkers, Tumor
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Adenoma
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Predictive Value of Tests
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Chromatography, Affinity
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Sensitivity and Specificity
研究类型:
Diagnostic_studies
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Prognostic_studies
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Screening_studies
限制:
Adult
/
Aged
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Aged80
/
Female
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Humans
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Male
国家/地区名称主题:
Asia
语言:
En
期刊:
Gut and Liver
年:
2015
类型:
Article