The retrospective study of serum aspergillus galactomannan (GM) antigen assay in invasive aspergillosis on hematological diseases / 中华血液学杂志
Chinese Journal of Hematology
; (12): 498-501, 2013.
Article
在 Zh
| WPRIM
| ID: wpr-235417
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the optical density index of serum aspergillus galactomannan (GM) assay and invasive aspergillosis (IA).</p><p><b>METHODS</b>From Jan 2008 to Dec 2011, 825 hematological diseases patients with neutrophil count <0.5×10⁹/L⁹ by continuous blood count tests were admitted into our hospital. The optical density index of GM assay was ≥0.5 at least once. Of 825 patients, 247 cases were manifested as fever during hospitalization. The optical density index of GM antigen was detected by enzyme-linked immunosorbent assay, and the sensitivity and specificity of optical density ranged in 0.5-1.5.</p><p><b>RESULTS</b>In this study, the sensitivity and specificity of GM assay with continuous twice samples (73% and 93%, respectively) were higher than single sample (66% and 80%, respectively) when optical density index ≥1.0. 69 cases were diagnosed as proven IA with the incidence rate of 8.36%.</p><p><b>CONCLUSION</b>The cut-off level for serum GM antigen assay should be decided as optical density index in two continuous samples of ≥1.0.</p>
全文:
1
索引:
WPRIM
主要主题:
Aspergillosis
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Blood
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Enzyme-Linked Immunosorbent Assay
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Sensitivity and Specificity
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Diagnosis
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Allergy and Immunology
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Hematologic Diseases
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Mannans
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Microbiology
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Antigens, Fungal
研究类型:
Diagnostic_studies
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Observational_studies
限制:
Adolescent
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Adult
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Aged
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Female
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Humans
/
Male
语言:
Zh
期刊:
Chinese Journal of Hematology
年:
2013
类型:
Article