Decreased expression of calcium-sensing receptor involved in the progression of diabetic cardiomyopathy / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 35-37, 2015.
Article
在 Zh
| WPRIM
| ID: wpr-243439
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the dynamic expression of calcium-sensing receptor(CaSR) in myocardium of diabetic rats.</p><p><b>METHODS</b>Thirty male Wistar rats were randomly divided into 3 groups including control, diabetic-4 week and diabetic-8 week groups(n = 10). The type 2 diabetes mellitus models were established by intraperitoneal injection of streptozotocin (STZ, 30 mg/kg) after high-fat and high-sugar diet for one month. The cardiac morphology was observed by electron microscope. Western blot analyzed the expression of CaSR, phospholamban (PLN), a calcium handling regulator, and Ca+-ATPase(SERCA) in cardiac tissues.</p><p><b>RESULTS</b>Compared with control group, the expressions of CaSR and SERCA were decreased, while the expression of PLN was significantly increased in a time-dependent manner in diabetic groups. Meanwhile diabetic rats displayed abnormal cardiac structure.</p><p><b>CONCLUSION</b>These results indicate that the CaSR expression of myocardium is reduced in the progression of DCM, and its potential mechanism may be related to the imnaired intracellular calcium homeostasis.</p>
全文:
1
索引:
WPRIM
主要主题:
Pathology
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Calcium-Binding Proteins
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Rats, Wistar
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Streptozocin
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Disease Progression
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Receptors, Calcium-Sensing
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Diabetes Mellitus, Experimental
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Diabetes Mellitus, Type 2
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Sarcoplasmic Reticulum Calcium-Transporting ATPases
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Diabetic Cardiomyopathies
限制:
Animals
语言:
Zh
期刊:
Chinese Journal of Applied Physiology
年:
2015
类型:
Article