Study on the immuno-effects of recombinant hepatitis B vaccination in adults / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 697-699, 2003.
Article
在 Zh
| WPRIM
| ID: wpr-246453
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the immuno-effects of hepatitis B (HB) vaccination in adults.</p><p><b>METHODS</b>Five groups were sampled by means of cluster sampling, and serum HBsAg, anti-HBs and anti-HBc were tested in every group at people aged from 18 to 50. Recombinant HB vaccine was injected to the ones that HBsAg, anti-HBs and anti-HBc were all negative. Concentration of anti-HBs in serum was tested after one year and three years of vaccination. Immuno-effects of recombinant HB vaccination in adults at different ages and between sexes, were then calculated.</p><p><b>RESULTS</b>Good immuno-effects of recombinant HB vaccination in adults were noticed. After one year and three years of vaccination with 5 micro g recombinant HB vaccine, the anti-HBs positive rates were 82.76%, 70.77% while the serum concentrations of anti-HBs were 55.91 mIU/ml and 35.41 mIU/ml respectively. When 10 micro g was used, the concentrations were 83.74%, 72.22%, 56.89 mIU/ml and 30.29 mIU/ml respectively. The effects did not show significant differences between different doses on 10 micro g and of 5 micro g. Concentration of anti-HBs reduced when time went by. The factors such as age and sex influenced the effects of immunity on recombinant HB vaccination.</p><p><b>CONCLUSION</b>Good immunity could be obtained when recombinant hepatitis B was vaccinated in vulnerable population aged 18 to 50.</p>
全文:
1
索引:
WPRIM
主要主题:
Blood
/
Vaccines, Synthetic
/
Vaccination
/
Hepatitis B Vaccines
/
Allergy and Immunology
/
Hepatitis B
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Hepatitis B Antibodies
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Hepatitis B Core Antigens
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Hepatitis B Surface Antigens
限制:
Adolescent
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Adult
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Female
/
Humans
/
Male
语言:
Zh
期刊:
Chinese Journal of Epidemiology
年:
2003
类型:
Article