The efficacy and toxicity of the FUDR-based regimen in the treatment of advanced non-small cell lung cancer / 中国肺癌杂志

ABSTRACT

<p><b>BACKGROUND</b>To evaluate the efficacy and toxicity of the FUDR-based regimen in the treatment of advanced non-small cell lung cancer.</p><p><b>METHODS</b>Fifty patients in group A received the L/FUDR-EP regimen, while 42 patients in group B were given the L/FEP regimen. The response and toxicity were evaluated after three courses of treatment.</p><p><b>RESULTS</b>The therapeutic response of group A and group B were 40.0% and 38.1% respectively (P > 0.05). The toxicities such as marrow inhibition, gastrointestinal symptoms, alopecia and local phlebitis were remarkably lower in group A than those of group B (P < 0.01).</p><p><b>CONCLUSIONS</b>The FUDR based regimen is effective to the advanced NSCLC, and its toxicity is lower than 5-FU.</p>