Allogeneic peripheral blood hematopoietic stem cell transplantation for post-operatively treating acute non-lymphocytic leukemia patient complicated with renal cell carcinoma: one case report / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 203-206, 2008.
Article
在 Zh
| WPRIM
| ID: wpr-253350
Responsible library:
WPRO
ABSTRACT
The aim of this study was to evaluate the safety and efficacy of allogeneic hematopoietic peripheral blood stem cell transplantation (allo-PBHSCT) for post-operative therapy of acute non-lymphocytic leukemia (ANLL) patient complicated with renal cell carcinoma (RCC). One ANLL patient complicated with RCC underwent an myeloablative HLA-identical relative allo-PBHSCT after RCC operation. The conditioning regimen consisted of total body irradiation, cyclophosphamide and cytarabine. Graft versus host disease (GVHD) prophylaxis regimen composed of cyclosporine A, myco-phenolate mofetil and short course of methotrexate. The results indicated that the patient achieved engraftment 16 days after transplantation with full donor-type chimerism detected by STR-PCR at 30 and 100 days after transplantation. No acute or chronic GVHD and any severe complication developed. As of March 2007, the patient remains without disease at follow-up of 44 months. In conclusion, allo-HSCT procedure is feasible and effective for post-operative therapy of ANLL patient complicated with RCC without severe toxicity.
全文:
1
索引:
WPRIM
主要主题:
Postoperative Period
/
General Surgery
/
Therapeutics
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Transplantation, Homologous
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Carcinoma, Renal Cell
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Leukemia, Myeloid, Acute
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Peripheral Blood Stem Cell Transplantation
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Graft vs Host Disease
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Kidney Neoplasms
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Neoplasms, Multiple Primary
限制:
Adult
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Humans
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Male
语言:
Zh
期刊:
Journal of Experimental Hematology
年:
2008
类型:
Article