The effects of sodium salicylate on the expression of GABAalpha, NR1 and hearing response properties of inferior colliculus neurons in mice / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 200-205, 2006.
Article
在 Zh
| WPRIM
| ID: wpr-254565
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To study the effects of sodium salicylate on the expression of GABAalpha NR1 and hearing response properties of inferior colliculus neurons in mice.</p><p><b>METHODS</b>Thirty-six kunming mice were divided into three groups (A, B, C,). The expression of GABAalpha NR1 were measured by using RT-PCR. The intensity-rates functions, intensity-latency functions and frequency-turning curves were recorded by extracellular electrophysiological recording techniques.</p><p><b>RESULTS</b>(1) The expression of GABAalpha mRNA of B group was decreased remarkably than the control group (A group, P < 0.05), there weren't noticeable differences between A group and C group (P > 0.05). The expression of NR1 mRNA of B group was increased remarkably than the control group (A group, P < 0.01), there were noticeable differences between A group and C group P < 0.05). (2) The intensity-rates functions, intensity-latency functions were monotonic while the frequency-turning curves were more broad when sodium salicylate was given. (3) The intensity-rates functions, intensity-latency functions were non-monotonic while the frequency-turning curves were sharpened after lidocaine was given.</p><p><b>CONCLUSIONS</b>(1) The results suggested that administration of sodium salicylate decreased the expression of GABAalpha while increased the expression of NR1mRNA. (2) The intensity-rates functions, intensity-latency functions were monotonic, the frequency-turning curves were more broad when salicylate was given and the changes above could be reversed by given lidocaine.</p>
全文:
1
索引:
WPRIM
主要主题:
Pharmacology
/
Physiology
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Acoustic Stimulation
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Inferior Colliculi
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Sodium Salicylate
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Receptors, N-Methyl-D-Aspartate
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Gamma-Aminobutyric Acid
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Metabolism
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Mice, Inbred Strains
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Neurons
限制:
Animals
语言:
Zh
期刊:
Chinese Journal of Applied Physiology
年:
2006
类型:
Article