Neurobehavioral Assessment of Rats Exposed to Yttrium Nitrate during Development / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
; (12): 281-290, 2015.
Article
在 En
| WPRIM
| ID: wpr-264587
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study was to assess the effects of yttrium nitrate on neurobehavioral development in Sprague-Dawley rats.</p><p><b>METHODS</b>Dams were orally exposed to 0, 5, 15, or 45 mg/kg daily of yttrium nitrate from gestation day (GD) 6 to postnatal day (PND) 21. Body weight and food consumption were monitored weekly. Neurobehavior was assessed by developmental landmarks and reflexes, motor activity, hot plate, Rota-rod and cognitive tests. Additionally, brain weights were measured on PND 21 and 70.</p><p><b>RESULTS</b>No significant difference was noted among all groups for maternal body weight and food consumption. All yttrium-exposed offspring showed an increase in body weight on PND 21; however, no significant difference in body weight for exposed pups versus controls was observed 2 weeks or more after the yttrium solution was discontinued. The groups given 5 mg/kg daily decreased significantly in the duration of female forelime grip strength and ambulation on PND 13. There was no significant difference between yttrium-exposed offspring and controls with respect to other behavioral ontogeny parameters and postnatal behavioral test results.</p><p><b>CONCLUSION</b>Exposure of rats to yttrium nitrate in concentrations up to 45 mg/kg daily had no adverse effects on their neurobehavioral development.</p>
Key words
全文:
1
索引:
WPRIM
主要主题:
Prenatal Exposure Delayed Effects
/
Yttrium
/
Pain Measurement
/
Random Allocation
/
Rats, Sprague-Dawley
/
Risk Assessment
/
Maze Learning
/
Rotarod Performance Test
/
Dose-Response Relationship, Drug
/
Environmental Pollutants
研究类型:
Etiology_studies
/
Risk_factors_studies
限制:
Animals
/
Pregnancy
语言:
En
期刊:
Biomedical and Environmental Sciences
年:
2015
类型:
Article