Effects of Shengmai injection on testicular injury after torsion/detorsion in rats of different ages / 中华男科学杂志
National Journal of Andrology
; (12): 185-188, 2011.
Article
在 Zh
| WPRIM
| ID: wpr-266192
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the different effects of Shengmai injection on testicular injury after testis torsion/detorsion in rats of different ages.</p><p><b>METHODS</b>Sixteen healthy male SD rats aged 3, 6 and 12 weeks were equally randomized into an experimental group (testicular torsion/detorsion plus Shengmai injection) and a control group (testicular torsion/detorsion plus saline). The rat models of testicular torsion were killed 24 h after surgery for the measurement of total antioxidant capacity (T-AOC), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the testis.</p><p><b>RESULTS</b>Compared with the controls, the 3- and 6-week-old rats of the experimental group showed no significant changes in T-AOC, SOD activity and MDA content (P > 0.05), while the 12-week-old experimental rats exhibited a remarkable increase in SOD and T-AOC and an obvious decrease in MDA content (P < 0.05).</p><p><b>CONCLUSION</b>Shengmai injection has a protective effect against acute ischemia-reperfusion testicular injury after torsion/detorsion in rats, but the effect varies with the age, more obvious in older ones.</p>
全文:
1
索引:
WPRIM
主要主题:
Spermatic Cord Torsion
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Superoxide Dismutase
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Testis
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Wounds and Injuries
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Drugs, Chinese Herbal
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Reperfusion Injury
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Rats, Sprague-Dawley
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Therapeutic Uses
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Drug Combinations
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Drug Therapy
限制:
Animals
语言:
Zh
期刊:
National Journal of Andrology
年:
2011
类型:
Article