Chaiqiyigan granula enhances Taxol-induced growth inhibition of hepatocellular carcinoma xenografts in nude mice: an in vivo fluorescence imaging study / 南方医科大学学报
Journal of Southern Medical University
; (12): 1042-1045, 2012.
Article
在 Zh
| WPRIM
| ID: wpr-268937
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Chaiqiyigan Granula (CG) and Taxol on the growth of hepatocellular carcinoma (HCC) xenografts and expression of Bax, p53 and VEGF in nude mice.</p><p><b>METHODS</b>Whole-body fluorescence imaging was used to visualize the growth of HCC in nude mice bearing hepG2/EGFP cell xenograft. Immunohistochemistry was used to determine the content of Bax, p53 and vascular endothelial growth factor (VEGF) in the tumor tissues.</p><p><b>RESULTS</b>Compared with normal saline, Taxol alone and in combination with CG significantly inhibited the growth of HCC xenografts in the nude mice. The combined treatment with CG and Taxol produced a stronger inhibitory effect on the tumor growth than Taxol alone in the third and fourth weeks. The volume and weight of the xenografts were decreased in the combined treatment group compared with those in saline treatment group. CG combined with Taxol increased the expression of Bax and reduced the expression of p53 and VEGF in the tumor xenografts.</p><p><b>CONCLUSION</b>CG can enhance the inhibitory effects of Taxol on the growth of HCC xenografts, and this effect is related to the up-regulation of Bax and down-regulation of p53 and VEGF expression in the tumor.</p>
全文:
1
索引:
WPRIM
主要主题:
Pathology
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Pharmacology
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Drugs, Chinese Herbal
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Tumor Suppressor Protein p53
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Paclitaxel
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Carcinoma, Hepatocellular
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Xenograft Model Antitumor Assays
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Cell Line, Tumor
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Vascular Endothelial Growth Factor A
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Bcl-2-Associated X Protein
研究类型:
Prognostic_studies
限制:
Animals
/
Humans
语言:
Zh
期刊:
Journal of Southern Medical University
年:
2012
类型:
Article