Impact of cytomegalovirus infections on T lymphocyte subsets in children with β-thalassemia major early after allogeneic hematopoietic stem cell transplantation / 南方医科大学学报
Journal of Southern Medical University
; (12): 1008-1011, 2012.
Article
在 Zh
| WPRIM
| ID: wpr-268944
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of human cytomegalovirus (HCMV) infection on T lymphocyte subsets in children with β-thalassemia major (TM) during the initial 6 months after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).</p><p><b>METHODS</b>From January, 2010 to January, 2011, 35 children with TM underwent Allo-HSCT. Peripheral blood samples were obtained from the children 6 month after the transplantation to examine the changes of T lymphocytes subsets in relation to HCMV seropositivity.</p><p><b>RESULTS</b>Thirteen children were found seropositive and 22 were seronegative for HCMV. The HCMV-seropositive children had a higher CD8⁺ cell percentage but a lower CD4⁺ cell percentage than those without HCMV infection. Compared with those seronegative for HCMV, the children with HCMV seropositivity showed increased percentages of CD8⁺ cells and CD8⁺CD28⁻ cells with a decreased percentage of CD8⁺CD28⁺ cells. A positive linear correlation was found between the percentages of CD8⁺CD28⁻ cells and CD8⁺ cells.</p><p><b>CONCLUSION</b>HCMV infection can lead to the accumulation of CD8⁺CD28 cells to cause increased CD8⁺ T cells in the peripheral blood in TM children after Allo-HSCT. The percentages of CD8⁺CD28⁻ cells has a positive linear correlation to that of CD8⁺ cells.</p>
全文:
1
索引:
WPRIM
主要主题:
Postoperative Period
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General Surgery
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Virology
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T-Lymphocyte Subsets
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Beta-Thalassemia
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Cytomegalovirus Infections
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Hematopoietic Stem Cell Transplantation
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CD8-Positive T-Lymphocytes
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Cytomegalovirus
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Allergy and Immunology
限制:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
语言:
Zh
期刊:
Journal of Southern Medical University
年:
2012
类型:
Article