Effect of beta radiation on TGF-beta1 and bFGF expression in hyperplastic prostatic tissues / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 49-54, 2005.
Article
在 En
| WPRIM
| ID: wpr-270873
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the transforming growth factor beta1 (TGF-beta1) and basic fibroblast growth factor (bFGF) expressions in benign prostatic hyperplasia (BPH) and the effect of beta-radiation.</p><p><b>METHODS</b>TGF-beta1 and bFGF expression was studied by means of an immunohistochemical method in nine normal prostatic (NP) tissues, 15 hyperplastic prostatic tissues and 35 hyperplastic prostatic tissues treated with 90Sr/90Y.</p><p><b>RESULTS</b>The TGF-beta1 expression in the epithelium and stroma of normal prostatic tissues was 68.2 % +/- 10.5 % and 29.7 % +/- 4.6 %, respectively, while it was 64.8 % +/- 9.3 % and 28.6 % +/- 4.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, TGF-beta1 expression in the epithelia and stroma of BPH treated with 90Sr/90Y increased significantly (P <0.01). The bFGF expression in epithelia and stroma of normal prostatic tissues was 17.4 % +/- 3.7 % and 42.5 % +/- 6.8 %, respectively, and was 46.3 % +/- 8.2 % and 73.2 % +/- 12.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, expressions of bFGF in the epithelia and stroma of BPH treated with a 90Sr/90Y prostatic hyperplasia applicator decreased significantly (P <0.01).</p><p><b>CONCLUSION</b>Exposure of beta-rays had noticeable effects on BPH tissues, enhancing TGF-beta1 expression and inhibiting bFGF expression.</p>
全文:
1
索引:
WPRIM
主要主题:
Prostate
/
Prostatic Hyperplasia
/
Radiation Effects
/
Radiotherapy
/
Strontium Radioisotopes
/
Yttrium Radioisotopes
/
Beta Particles
/
Immunohistochemistry
/
Case-Control Studies
/
Gene Expression
研究类型:
Observational_studies
/
Risk_factors_studies
限制:
Aged
/
Aged80
/
Humans
/
Male
语言:
En
期刊:
Asian Journal of Andrology
年:
2005
类型:
Article