Influence of apolipoprotein E gene polymorphism on the lipid regulation by xuezhikang capsule / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 688-691, 2009.
Article
在 Zh
| WPRIM
| ID: wpr-273643
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the influence of apolipoprotein E (ApoE) gene polymorphism on the lipid metabolism regulatory effect of Xuezhikang Capsule (XZKC).</p><p><b>METHODS</b>ApoE polymorphism of 74 patients with hyperlipidemia was detected by gene sequencing method, and their plasma levels of total cholesterol (TC), triglyceride (TG), high- and low-density lipoprotein cholesterol (HDL-C and LDL-C) were determined before and after they received a 6-week treatment of XZKC, for analyzing the relationship between ApoE gene polymorphism and the changes of various blood lipids associated indices.</p><p><b>RESULTS</b>The effect of XZKC on reducing TG in the epsilon2 allele (E2/E2 and E2/E3 genotypes) was higher than that in the E3/E3 genotypes and epsilon4 allele (E3/E4 and E4/E4 genotypes), while on increasing HDL-C, it showed more effect in the epsilon4 allele (E3/E4 and E4/E4 genotypes) than that in the epsilon2 allele (E2/E2 and E2/E3 genotypes) and E3/E3 genotypes.</p><p><b>CONCLUSION</b>Patients' ApoE gene polymorphism could influence the lipid regulatory effect of XZKC, embodying mainly by raising HDL-C and reducing TG in patients with different ApoE genotypes to different extents.</p>
全文:
1
索引:
WPRIM
主要主题:
Apolipoproteins E
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Polymorphism, Genetic
/
Triglycerides
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Blood
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Drugs, Chinese Herbal
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Therapeutic Uses
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Drug Therapy
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Lipid Metabolism
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Genetics
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Genotype
限制:
Adult
/
Aged
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Female
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Humans
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Male
语言:
Zh
期刊:
Chinese Journal of Integrated Traditional and Western Medicine
年:
2009
类型:
Article