Clinical analysis of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 971-974, 2012.
Article
在 Zh
| WPRIM
| ID: wpr-278454
Responsible library:
WPRO
ABSTRACT
The objective of this study was to explore the incidence and therapeutic efficacy of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The clinical data of 140 patients undergoing allo-HSCT in our department of hematology from 2010-01 to 2012-01 were retrospectively analyzed. The results showed that the incidence of CMV infection was 4.3% (48/140), the time for the first detection of positive CMV-DNA was at day 45 (33 to 68) after allo-HSCT, and the CMV quantitative range was 1.25×10(3) - 5.5×10(6). There were 2 cases of CMV-related interstitial pneumonia and 5 cases of hemorrhagic bladder inflammation. A total of 65 patients suffered from graft versus host disease (GVHD), in which 32 cases (49.2%) were accompanied with CMV infection, CMV-DNA negative in patients treated with ganciclovir, foscarnet sodium anti-CMV was at day 45 (33 to 68) with the effective rate of 100%. 12 patients with CMV infection were accompanied with transient neutropenia and thrombocytopenia. It is concluded that after allo-HSCT the CMV infection occurs frequently. The patients with GVHD have a higher incidence of CMV infection. Ganciclovir and foscarnet sodium are reliable to be used for treatment of CMV infection with fewer adverse reactions.
全文:
1
索引:
WPRIM
主要主题:
Transplantation, Homologous
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Ganciclovir
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Retrospective Studies
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Risk Factors
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Foscarnet
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Cytomegalovirus Infections
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Hematopoietic Stem Cell Transplantation
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Therapeutic Uses
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Drug Therapy
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Graft vs Host Disease
研究类型:
Etiology_studies
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Observational_studies
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Risk_factors_studies
限制:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
语言:
Zh
期刊:
Journal of Experimental Hematology
年:
2012
类型:
Article