Effects of human urinary tissue kallikreins on vasodilation of basilar artery in rabbits with symptomatic cerebral vasospasm / 中华外科杂志
Chinese Journal of Surgery
; (12): 697-700, 2009.
Article
在 Zh
| WPRIM
| ID: wpr-280598
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effects of urinary kallidinogenase on subarachnoid hemorrhage (SAH) in rabbits.</p><p><b>METHODS</b>Rabbits symptomatic cerebral vasospasm model was built though Endo method, among the 40 rabbits, 8 died or had severe nervous system syndrome, the other 32 were randomly divided into 4 groupsgroup A, control group, injection of normal saline to the cisterna magna;group B, subarachnoid hemorrhage;group C, injection of human urinary tissue kallikreins;group D, treated with Nimodipine. The behavior scores, neurological scores and cerebral angiography changes were observed.</p><p><b>RESULTS</b>Food intake obviously decreased and neurological deficit were seen in group B, while which were attenuated in group C and group D, and group A was normal. Comparing the diameter of basilar artery was (1.9 +/- 0.3) mm before SAH, the diameter of group B 4 d later was (1.5 +/- 0.3) mm, 7 d later (1.4 +/- 0.3) mm, the difference was significant (P < 0.05). Comparing with group C on the day 4th and 7th, the diameters of basilar artery were significantly different (P < 0.001). Comparing with group D on the day 4th, 7th and 14th, there was no obvious improvement.</p><p><b>CONCLUSION</b>Urinary kallidinogenase and Nimodipine can obviously alleviate symptomatic cerebral vasospasm in rabbits remarkably, but the former's effect of attenuating vasospasm is better than that of Nimodipine.</p>
全文:
1
索引:
WPRIM
主要主题:
Vasodilator Agents
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Nimodipine
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Random Allocation
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Vasospasm, Intracranial
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Tissue Kallikreins
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Therapeutic Uses
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Disease Models, Animal
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Drug Therapy
研究类型:
Clinical_trials
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Prognostic_studies
限制:
Animals
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Female
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Humans
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Male
语言:
Zh
期刊:
Chinese Journal of Surgery
年:
2009
类型:
Article