Distribution characteristics of rs1891385A/C and rs10975519C/T polymorphisms of interleukin-33 gene in Guangxi population / 南方医科大学学报
Journal of Southern Medical University
; (12): 964-968, 2016.
Article
在 Zh
| WPRIM
| ID: wpr-286865
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the race- and gender-specific distribution characteristics of rs1891385A/C and rs10975519C/T polymorphism of interleukin-33 (IL-33) gene in Zhuang and Han populations.</p><p><b>METHODS</b>The polymorphisms of rs1891385A/C and rs10975519C/T of IL-33 gene in 283 subjects from Guangxi Zhuang Autonomous Region were analyzed with single base extension (PCR-SEB) and DNA sequencing to analyze the differences in their distribution frequencies between genders and between Zhuang and Han populations.</p><p><b>RESULTS</b>Three genotypes (AA, AC and CC) were found in rs1891385A/C with frequencies of 64.3%, 32.5% and 3.2%, respectively. The genotype and allele frequencies of rs1891385A/C in this Guangxi population showed no significant difference between Zhuang and Han subpopulations and between genders (P>0.05), but differed significantly from those in European and African black populations (P<0.01). Three genotypes (CC, CT and TT) were identified in rs10975519C/T with frequencies of 34.3%, 53.0%, and 12.7%, respectively, showing no significant ethnic or gender-specific differences in this population (P>0.05). The genotype frequency of rs10975519C/T in this population differed significantly from those in the European and Japanese populations (P<0.01), but the allele frequencies only showed significant differences from those in the European population (P<0.01).</p><p><b>CONCLUSION</b>rs1891385A/C and rs10975519C/T polymorphisms of IL-33 gene show a race-specific difference.</p>
全文:
1
索引:
WPRIM
主要主题:
Polymorphism, Genetic
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Ethnicity
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China
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Polymerase Chain Reaction
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Sequence Analysis, DNA
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Polymorphism, Single Nucleotide
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Black People
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Asian People
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White People
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Interleukin-33
研究类型:
Prognostic_studies
限制:
Female
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Humans
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Male
国家/地区名称主题:
Asia
语言:
Zh
期刊:
Journal of Southern Medical University
年:
2016
类型:
Article