Different species of human rhinovirus infection in children with acute respiratory tract infections in Beijing / 中华儿科杂志
Chinese Journal of Pediatrics
; (12): 903-908, 2013.
Article
在 Zh
| WPRIM
| ID: wpr-288815
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To understand the clinical characteristics of different groups human rhinovirus (HRV)-A, B and C infection in children with acute respiratory tract infections (ARI) in Beijing.</p><p><b>METHOD</b>Respiratory tract specimens (n = 1412) collected from children with ARI during Jan. 2011 to Dec. 2012 were tested for HRV by using semi-nested PCR. Gene fragments of VP4/VP2 capsid protein amplified from HRV positive specimens were sequenced for HRV genotype confirmation. Then epidemiological characteristics of these HRV-positive cases were analyzed.</p><p><b>RESULT</b>Among these 1412 specimens tested, 103 (7.3%) were HRV positive, including 54 (52.4%) positive for HRV-A, 14 (13.6%) for HRV-B, 35 (34.0%) for HRV-C determined by sequence analysis. The positive rates of HRV-A, B and C (2.5%, 16/638; 0.3%, 2/638 and 1.3%, 8/638) in children with acute upper respiratory tract infections (URI) were lower than those (5.8%, 36/623; 1.8%, 11/623 and 3.9%, 24/623) in children with acute lower respiratory tract infections (LRI) (P = 0.003, 0.011, 0.003). In children with LRI, the positive rates of HRV-A, C were similar to each other (P = 0.112), and both were higher than that of HRV-B (P = 0.000, P = 0.026). The severity of ARI among children positive for different groups HRV showed no significant difference evaluated by Kruskal-Wallis H test (Hc = 0.044, P > 0.05), as well as that between children co-infected with HRV and other viruses and those infected with HRV only evaluated by Wilcoxon rank sum test (Zc = 0.872, P > 0.05).</p><p><b>CONCLUSION</b>HRV is one of important pathogens for children with ARI, especially LRI in Beijing. The positive rates of HRV-A and HRV-C are similar to each other, and both are higher than that of HRV-B. No significant difference was shown among children with different HRV genotypes by evaluation of the severity of ARI, and co-infections of HRV with other viruses do not significantly increase the severity of ARI.</p>
全文:
1
索引:
WPRIM
主要主题:
Phylogeny
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Respiratory Tract Infections
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Rhinovirus
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Virology
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Severity of Illness Index
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China
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Acute Disease
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Epidemiology
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Classification
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Sequence Analysis, RNA
限制:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
国家/地区名称主题:
Asia
语言:
Zh
期刊:
Chinese Journal of Pediatrics
年:
2013
类型:
Article