Efficacy of Vancomycin-beta-lactam Combinations Against Heterogeneously Vancomycin-Resistant Staphylococcus aureus (hetero-VRSA)
Journal of Korean Medical Science
; : 319-324, 2003.
Article
在 En
| WPRIM
| ID: wpr-29062
Responsible library:
WPRO
ABSTRACT
There have been conflicting data about the interactions between vancomycin and beta-lactam agents against Staphylococcus aureus strains with heterogeneous resistance to vancomycin. We evaluated the efficacy of these combinations against Mu 3 and heterogeneously vancomycin-resistant S. aureus (hetero-VRSA) strains which were isolated from Korean patients using a population analysis method. Antagonistic effects were observed when less than 1 g/mL of beta-lactam antibiotics was combined with vancomycin, whereas synergistic effects were noticed with more than 4 microgram/mL of beta-lactam antibiotics. The antagonistic effects at low concentrations of beta-lactams were most prominent at 2 microgram/mL of vancomycin, which were the vancomycin MICs of tested hetero-VRSA strains. This study showed the variable effects of vancomycin- beta-lactam combinations depending on the concentrations of beta-lactam antibiotics and this property could be used to develop screening methods for hetero-VRSA strains.
Key words
全文:
1
索引:
WPRIM
主要主题:
Oxacillin
/
Staphylococcus aureus
/
In Vitro Techniques
/
Vancomycin
/
Microbial Sensitivity Tests
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Cefotaxime
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Beta-Lactam Resistance
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Vancomycin Resistance
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Drug Synergism
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Anti-Bacterial Agents
限制:
Humans
语言:
En
期刊:
Journal of Korean Medical Science
年:
2003
类型:
Article