Resistance and treatment strategy of gastrointestinal stromal tumor target therapy / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 309-312, 2012.
Article
在 Zh
| WPRIM
| ID: wpr-290798
Responsible library:
WPRO
ABSTRACT
Gastrointestinal stromal tumor(GIST) originates from interstitial cells of Cajal(ICCs). Tyrosine kinase inhibitors(TKI) such as imatinib and sunitinib, are effective agents besides surgery. However some GIST can become primarily or secondarily resistant to those drugs. The difference in gene mutation types and secondary gene mutation is the main cause. When the GIST is proved to be drug resistance, reasonable personal treatment strategies based on individualized medicine should be made to improve outcomes and quality of life.
全文:
1
索引:
WPRIM
主要主题:
Piperazines
/
Pyrimidines
/
Pyrroles
/
Benzamides
/
Drug Resistance, Neoplasm
/
Therapeutic Uses
/
Gastrointestinal Stromal Tumors
/
Protein Kinase Inhibitors
/
Drug Therapy
/
Imatinib Mesylate
限制:
Humans
语言:
Zh
期刊:
Chinese Journal of Gastrointestinal Surgery
年:
2012
类型:
Article