Roles of phosphatases in pathogen infection: a review / 生物工程学报
Chinese Journal of Biotechnology
; (12): 154-163, 2012.
Article
在 Zh
| WPRIM
| ID: wpr-304504
Responsible library:
WPRO
ABSTRACT
Phosphatases play a key role not only in cell physiological functions of an organism, but also in host-pathogen interactions. Many studies demonstrated that some Gram-negative pathogenic bacteria could evade host immunity and promote pathogenicity by injecting phosphatases into host cells through type III secretion system. However, there were few reports about pathogenic fungi evading the immunity of hosts. Our researches indicated that the entomogenic fungus Metarhizium anisopliae could dephosphorylate the signal transduction substance of locust humoral immunity specifically in vitro by secreting extracellular protein tyrosine phosphatase, which implied that the fungus might interfere with the immune defense of locust. To provide reference for further studies of the functions of phosphatases, we reviewed the types of phosphatases and their roles in pathogen infection.
全文:
1
索引:
WPRIM
主要主题:
Physiology
/
Fungal Proteins
/
Classification
/
Phosphoric Monoester Hydrolases
/
Bodily Secretions
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Allergy and Immunology
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Metarhizium
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Host-Pathogen Interactions
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Fungi
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Gram-Negative Bacteria
限制:
Animals
语言:
Zh
期刊:
Chinese Journal of Biotechnology
年:
2012
类型:
Article