Effect of new qingkailing injection on cerebral edema following intracerebral hemorrhage in rats / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 244-247, 2006.
Article
在 Zh
| WPRIM
| ID: wpr-331710
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of New Qingkailing injection (NQKLI) on cerebral edema following intracerebral hemorrhage (ICH) induced by collagenase VII in rats.</p><p><b>METHODS</b>After being established into ICH model by collagenase VII, rats were treated with NQKLI by intraperitoneal injection. Forty-eight hrs later, brain contents of water was detected with wet and dry method, calcium content in brain was detected by atomic spectrophotometer, tumor necrosis factor-alpha (TNF-alpha) in brain tissue was determined by liquid competitive ibhibitory immunoassay, and serum matrix metalloproteinase-9 (MMP-9) were detected with enzyme-linked immunosorbent assay (ELISA) respectively.</p><p><b>RESULTS</b>NQKLI reduced the contents of water, calcium and TNF-alpha content of brain tissue and serum MMP-9 in rats with ICH.</p><p><b>CONCLUSION</b>NQKLI could alleviate both vasogenic and cytotoxic cerebral edema by prohibiting calcium over-load, protecting basilar membrane and eliminating inflammation.</p>
全文:
1
索引:
WPRIM
主要主题:
Therapeutics
/
Blood
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Brain Edema
/
Drugs, Chinese Herbal
/
Random Allocation
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Cerebral Hemorrhage
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Tumor Necrosis Factor-alpha
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Rats, Wistar
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Collagenases
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Neuroprotective Agents
研究类型:
Prognostic_studies
限制:
Animals
语言:
Zh
期刊:
Chinese Journal of Integrated Traditional and Western Medicine
年:
2006
类型:
Article