The expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To research the expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding.</p><p><b>METHODS</b>Detecting the expression of Bcl-2 and Bax protein in 40 cases of endometrium tissue of dysfunctional uterine bleeding patients with immunohistochemistry antibiotics protein-peroxide emzyme (SP)methods.</p><p><b>RESULTS</b>(1) The expression of Bcl-2 protein changes clearly and periodically in endometrium in normal cycle, the difference is obvious (P < 0.05). (2) The Bcl-2 protein develops with the hyperplasia in endometrium and the expression intensity is enhanced, the difference is obvious( P < 0.05). (3) The expression of Bax gene is masculine in endometrium in normal menstrual cycle. (4) The expression of Bax gene descends gradually with hyperplasia in uterine endometrium (P < 0.05).</p><p><b>CONCLUSION</b>Apoptosis of endometrium cell is restrained from the excessive expression of Bcl-2 protein and deficient expression of Bax protein, so the uterine endometrium gets to hyperplasia or notypical hyperplasia.</p>