Clinicopathologic features, prognosis and etiology of primary non-Hodgkin lymphoma of bone / 中华病理学杂志
Chinese Journal of Pathology
; (12): 90-93, 2007.
Article
在 Zh
| WPRIM
| ID: wpr-333962
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinicopathologic features, prognostic indicators and possible etiology of primary non-Hodgkin lymphoma of bone (PNHLB).</p><p><b>METHODS</b>The clinicopathologic features of 17 cases of PNHLB were reviewed. In-situ hybridization for Epstein-Barr virus early RNA (EBER) and polymerase chain reaction for bcl-2/JH gene rearrangement were performed using paraffin-embedded materials. The correlation between serum lactic dehydrogenase level, treatment options, international prognostic indicator (IPI) and immunophenotype with clinical outcome were analyzed.</p><p><b>RESULTS</b>The majority of the 17 cases studied was diffuse large B-cell lymphoma (94.1%). The 5-year survival rate was 68.8%. Unfavorable prognostic factors included high-risk IPI (P = 0.031) and bcl-2 overexpression (P = 0.028). Treatment options and expression of CD10, MUM-1 or bcl-6 did not correlate with clinical outcome (P > 0.05). Only 1 patient was positive for EBER, as demonstrated by in-situ hybridization.</p><p><b>CONCLUSIONS</b>The clinical outcome of PNHLB is relatively favorable. IPI and bcl-2 expression may serve as useful prognostic indicators. EBV is likely not related to pathogenesis of this type of lymphoma.</p>
全文:
1
索引:
WPRIM
主要主题:
Pathology
/
Prognosis
/
Ribosomal Proteins
/
Bone Neoplasms
/
Lymphoma, Non-Hodgkin
/
Gene Rearrangement
/
Neprilysin
/
Survival Rate
/
Immunophenotyping
/
Lymphoma, Large B-Cell, Diffuse
研究类型:
Etiology_studies
/
Prognostic_studies
限制:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
语言:
Zh
期刊:
Chinese Journal of Pathology
年:
2007
类型:
Article