Study on molecular mechanism of Euodiae Fructus on liver toxicity in MICE / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4865-4868, 2014.
Article
在 Zh
| WPRIM
| ID: wpr-341801
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the molecular mechanism of extracts from Euodia rutaecarpa on hepatotoxicity in mice.</p><p><b>METHOD</b>Totally 30 KM mice were divided into 3 groups and orally administrated extracts from E. rutaecarpa for consecutively 15 days. The expressions of Erkl/2, CDK8, CK1e, Stat3 and Src were detected by Western blotting method.</p><p><b>RESULT</b>The extracts from E. rutaecarpa could up-regulated Erkl/2, CDK8 and CK1e expressions (P <0.01) and down-regulate Stat3 and Src (P <0.01).</p><p><b>CONCLUSION</b>The molecular mechanism of E. rutaecarpa on hepatotoxicity may be correlated with Erkl/2, CDK8, CKle, Stat3 and Src signal molecules.</p>
全文:
1
索引:
WPRIM
主要主题:
Plants, Medicinal
/
Aspartate Aminotransferases
/
Triglycerides
/
Blood
/
Drugs, Chinese Herbal
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Signal Transduction
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Down-Regulation
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Up-Regulation
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Chemistry
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Gene Expression Regulation
限制:
Animals
语言:
Zh
期刊:
China Journal of Chinese Materia Medica
年:
2014
类型:
Article