Reprogramming in origin and development of leukemia stem/progenitor cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1123-1126, 2009.
Article
在 Zh
| WPRIM
| ID: wpr-343335
Responsible library:
WPRO
ABSTRACT
The success of yielding induced pluripotent stem (iPS) cells from human somatic cells demonstrates the important role of reprogramming in the formation of stem/progenitor cells and initiates the exploration of the origin of leukemia stem cells. In our previous work, we have found two types of leukemia, bona fide leukemia and non-bona fide leukemia. Different leukemias originate from different leukemia stem/progenitor cells which are critical to the genesis and evolution of leukemia. Bona fide leukemia and non-bona fide leukemia originate from leukemia stem cells and progenitor cells, respectively. Recent research suggests that different types of leukemia are influenced by the reprogramming state of their origin cells.