Altered expression of the HSD17B4 gene in esophageal squamous cell carcinoma and loss of heterozygosity analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 270-273, 2005.
Article
在 Zh
| WPRIM
| ID: wpr-343724
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alteration of the gene HSD17B4 in esophageal squamous cell carcinoma and its potential significance.</p><p><b>METHODS</b>The mRNA expression and loss of heterozygosity (LOH) of HSD17B4 in 40 primary esophageal tumors were detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and microsatellite analysis with the intragenic marker D5S1384 of the gene.</p><p><b>RESULTS</b>The frequencies of allelic loss of D5S1384 and the rate of down-regulation of gene HSD17B4 were 46.2% and 62.5%, respectively.</p><p><b>CONCLUSION</b>HSD17B4 may be a candidate tumor suppressor gene associated with esophageal squamous cell carcinoma.</p>
全文:
1
索引:
WPRIM
主要主题:
RNA, Messenger
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Esophageal Neoplasms
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Carcinoma, Squamous Cell
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Down-Regulation
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Gene Expression
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Gene Expression Regulation, Neoplastic
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Genes, Tumor Suppressor
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Microsatellite Repeats
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Loss of Heterozygosity
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Reverse Transcriptase Polymerase Chain Reaction
限制:
Adult
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Aged
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Female
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Humans
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Male
语言:
Zh
期刊:
Acta Academiae Medicinae Sinicae
年:
2005
类型:
Article