Application of array comparative genomic hybridization analysis for fetuses with growth anomalies / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 691-694, 2017.
Article
在 Zh
| WPRIM
| ID: wpr-344194
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the genetic etiology for fetuses featuring intrauterine growth anomalies using array-based comparative genomic hybridization (aCGH).</p><p><b>METHODS</b>Forty-nine fetuses were enrolled in this study. Genomic DNA of the abortive tissues was analyzed with aCGH.</p><p><b>RESULTS</b>Fourteen (28.6%) samples were found with chromosomal aberrations, which included 8 chromosomal aneuploidies and 6 micro-aberrations (4 with known clinical pathogenecity and 2 with unknown clinical significance).</p><p><b>CONCLUSION</b>Numerical and structural chromosomal aberrations underlie a significant proportion of fetal growth anomalies. aCGH has provided an effective method for delineating their genetic cause.</p>
全文:
1
索引:
WPRIM
主要主题:
Prenatal Diagnosis
/
Congenital Abnormalities
/
Chromosome Aberrations
/
Comparative Genomic Hybridization
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DNA Copy Number Variations
/
Genetics
/
Methods
研究类型:
Diagnostic_studies
限制:
Adult
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Female
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Humans
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Pregnancy
语言:
Zh
期刊:
Chinese Journal of Medical Genetics
年:
2017
类型:
Article