The role of ADME evaluation in translation research of innovative drug / 药学学报
Acta Pharmaceutica Sinica
; (12): 19-29, 2011.
Article
在 Zh
| WPRIM
| ID: wpr-353335
Responsible library:
WPRO
ABSTRACT
New Chemical Entities (NCEs) development is a systematic long-term project that involves multiple disciplines. The translation research will help to build an advanced R&D system from the basic laboratory research, preclinical studies and clinical evaluation to clinical application of drug, for the purpose of shortening the R&D cycle and accelerate the launch of new drugs. In new drug R&D and its clinical application, drug disposition (absorption, distribution, metabolism, excretion, ADME) properties are important criteria for assessing drug-likeness of candidates. ADME evaluation of NCEs plays an important role in the translation research throughout innovative drug R&D process. Therefore, ADME evaluation at the early stage of drug design and development will be helpful to improve the success rate and reduce costs, and further access to safe, effective drugs.
全文:
1
索引:
WPRIM
主要主题:
Biological Transport
/
Pharmacokinetics
/
Pharmaceutical Preparations
/
Tissue Distribution
/
Drug Design
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Chemistry
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Drug Evaluation, Preclinical
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Absorption
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Translational Research, Biomedical
/
Metabolism
研究类型:
Prognostic_studies
语言:
Zh
期刊:
Acta Pharmaceutica Sinica
年:
2011
类型:
Article