Analysis of CD117 expression on leukemia cells / 中华血液学杂志
Chinese Journal of Hematology
; (12): 228-230, 2003.
Article
在 Zh
| WPRIM
| ID: wpr-354884
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of CD(117) on different types of leukemia and its significance.</p><p><b>METHODS</b>CD(117) expression was analysed by three-color flow cytometry with CD(45)/SSC gating strategy.</p><p><b>RESULTS</b>CD(117) was expressed in 68% of acute myeloid leukemia (AML) and 80% of chronic myeloid leukemia in blast crisis (CML-BC) cases, but in only 2% of acute lymphoblastic leukemia cases. CD(117) was negative in CML in chronic phase and chronic lymphocytic leukemia. Cases in AML, CD(117) was expressed in 72% of M(0)/M(1), 88% of M(2), 50% of M(4), 75% of M(5a), 100% of M(6) and 100% of M(7) cases but was less expressed in M(3) (39%) and M(5b) (29%) cases. Expression of CD(117) was more frequent than CD(34) and HLA-DR in M(3) and some M(2) cases. There was a significant inverse relationship between CD(117) and CD(14) expression in AML.</p><p><b>CONCLUSIONS</b>Analysis of CD(117) expression may be of help in distinguishing myeloid from lymphoid leukemia and leukemia clone from normal cells.</p>
全文:
1
索引:
WPRIM
主要主题:
Leukemia, Lymphoid
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Leukemia, Myeloid
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Proto-Oncogene Proteins c-kit
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Diagnosis
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Diagnosis, Differential
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Flow Cytometry
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Metabolism
研究类型:
Diagnostic_studies
限制:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
语言:
Zh
期刊:
Chinese Journal of Hematology
年:
2003
类型:
Article