In vitro effect of STI571 on expression of c-kit in bone marrow cells from patients with acute non-lymphocytic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 256-258, 2003.
Article
在 Zh
| WPRIM
| ID: wpr-355670
Responsible library:
WPRO
ABSTRACT
This study was designed to explore the influence of STI571, a tyrosine kinase inhibitor, on the expression of c-kit in the bone marrow cells from patients with acute non-lymphocytic leukemia (ANLL). The cells were exposed to various concentration of STI571 for 72 hours, the expression of c-kit mRNA and CD117 was assayed by RT-PCR and flow cytometry, respectively. The results showed that STI571 treatment induced concentration-dependent decrease of c-kit and CD117 expression, which was significant lower than that in group before treatment and untreated control groups (P < 0.05) and 0.1 micro mol/L STI571 group was significantly higher than that in 10 micro mol/L group (P < 0.05). It is concluded that STI571 has an obvious effect on the restraint of c-kit in ANLL cells.
全文:
1
索引:
WPRIM
主要主题:
Pathology
/
Pharmacology
/
Piperazines
/
Pyrimidines
/
Benzamides
/
Blood
/
RNA, Messenger
/
Bone Marrow Cells
/
Leukemia, Myeloid, Acute
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Gene Expression Regulation, Neoplastic
限制:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
语言:
Zh
期刊:
Journal of Experimental Hematology
年:
2003
类型:
Article