Correlation between VLA-4 integrin and hematopoietic cell migration / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 230-234, 2003.
Article
在 En
| WPRIM
| ID: wpr-355676
Responsible library:
WPRO
ABSTRACT
To clarify the relationship between VLA-4 (CD49d) expression and hematopoietic cell migrating direction, mice were injected subcutaneously with diluted rhG-CSF for different times. The expressions of CD49d on Sca-1(+) cells were examined by flow cytometry. The relations between CD49d expression and Sca-1(+) cell enumerations were performed by statistical analysis. The results showed that with the administration of G-CSF, the expressions of CD49d in bone marrow (BM) and peripheral blood (PB) declined, meanwhile the number of Sca-1(+) cells in peripheral blood reached the peak in sharp contrast to BM nucleated cell number dropping on the seventh to ninth day. When CD49d expression rose again, the PB Sca-1(+) cells descended with the rising of BM nucleated cell number. In conclusion, VLA-4 mediates the hematopoietic cell adhesion to BM microenvironment. The regulation of CD49d expression may result in different migrating direction of hematopoietic cell between bone marrow and peripheral blood.
全文:
1
索引:
WPRIM
主要主题:
Pharmacology
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Physiology
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Time Factors
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Blood
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Bone Marrow Cells
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Hematopoietic Stem Cells
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Cell Count
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Cell Movement
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Granulocyte Colony-Stimulating Factor
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Hematopoietic Stem Cell Mobilization
限制:
Animals
语言:
En
期刊:
Journal of Experimental Hematology
年:
2003
类型:
Article