Significance of galectin-3 and CD44v6 expression in differential diagnosis of thyroid nodules / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 547-550, 2005.
Article
在 Zh
| WPRIM
| ID: wpr-358574
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the difference of galectin-3 and CD44v6 expression between benign and malignant thyroid nodules, and to evaluate their clinical value in distinguishing thyroid cancer from benign thyroid nodules.</p><p><b>METHODS</b>The expression of galectin-3 and CD44v6 was immunohistochemically detected by the ABC method in 143 benign and malignant thyroid nodule samples.</p><p><b>RESULTS</b>Expression of these two markers in benign thyroid nodules: galectin-3 was negative in 10 cases of para-cancer normal tissue and 14 cases of benign nodules found in the other benign thyroid disease. It was weakly positive in 4 of 52 nodular goiter (7.7%). Also it was weakly positive in 2 of 22 follicular adenomas (9.1%). But all three eosinophilic follicular adenomas were diffusely or focally positive for galectin-3. CD44v6 was negative in 10 cases of para-cancer normal tissue, but positive in 4 of 14 nodular lesions found in benign thyroid diseases (28.6%). It was also positive in 16 of 52 nodular goiters (30.8%), and weakly positive in 7 of 22 follicular adenomas (31.8%). The two markers in malignant lesions: galectin-3 was positive in 50 of 52 thyroid adenocarcinoma (96.2%), CD44v6 was positive in 42 of 52 thyroid adenocarcinoma (80.8%). The positive rate of galectin-3 and CD44v6 expression in thyroid cancer was significantly higher than that in benign thyroid nodule and normal tissue (P < 0.001). The sensitivity, specificity and accuracy of galectin-3 combined with CD44v6 in differentiating benign from malignant thyroid nodule were 80.8%, 93.4%, 88.8%; they were 96.2%, 90.1%, 92.3% for Galectin-3 alone.</p><p><b>CONCLUSION</b>The immunohistochemical expression of galectin-3 and CD44v6 by the ABC method is significantly higher in thyroid cancers than in benign thyroid nodules, especially galectin-3 in thyrocyte being helpful in differentiating benign thyroid nodule from thyroid cancer.</p>
全文:
1
索引:
WPRIM
主要主题:
Thyroid Neoplasms
/
Immunohistochemistry
/
Glycoproteins
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Adenocarcinoma, Papillary
/
Biomarkers, Tumor
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Adenoma
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Thyroid Nodule
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Hyaluronan Receptors
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Galectin 3
/
Diagnosis
研究类型:
Diagnostic_studies
限制:
Female
/
Humans
/
Male
语言:
Zh
期刊:
Chinese Journal of Oncology
年:
2005
类型:
Article