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Clinical Analysis of Cases with Drug-induced Liver Injury for Kampo Medicine / 日本東洋医学雑誌
Kampo Medicine ; : 828-833, 2010.
Article 在 Ja | WPRIM | ID: wpr-376147
Responsible library: WPRO
ABSTRACT
We analyzed the clinical features of 21 cases with drug-induced liver injury due to Kampo medicines between the years 2000 and 2009 in our institute. The mean age in these cases was 55.2 ± 13.4 years. Five of the cases were men, and 16 were women. In 17 of the 21 cases, drug-induced liver injury had occurred within 3 months after beginning Kampo medicines. There were no subjective symptoms in 11 cases. Nine cases of both hepatocellular injury, and of mixed-type injury were seen. Causative Kampo medicines included an Ogon (<I>Scutellariae Radix</I>) component in 19 cases. A drug-induced lymphocyte stimulation test (DLST) was performed in 5 cases. The test was positive for Kampo medicines in only one of the 5 cases. Liver injury improved or normalized in 18 cases (85.7%) after discontinuing causative Kampo medicines. In another 2 cases, liver injury normalized after changing a Kampo medicine to the same prescription without Ogon. These results suggest that even if patients complain of no symptoms we must perform blood tests to check liver function within 3 months of prescribing Kampo medicines, especially those including Ogon, to facilitate early diagnosis of drug-induced liver injury.
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在谷歌搜索
索引: WPRIM 研究类型: Screening_studies 语言: Ja 期刊: Kampo Medicine 年: 2010 类型: Article
在谷歌搜索
索引: WPRIM 研究类型: Screening_studies 语言: Ja 期刊: Kampo Medicine 年: 2010 类型: Article