Study of the correlated risk factors for the sustained attentional function damage in patients with mild Alzheimer's disease / 中华老年医学杂志

ABSTRACT

Objective To explore the condition and the related risk factors for attention function damage in patients with mild Alzheimer'S disease(AD). Methods　Continuous performance test (CPT)was performed in 100 healthy elder people and in 68 patients with mild AD before treatment and after 8 weeks'treatment.Mini-mental state examination(MMSE)and behavioral pathology in Alzheimer's disease rating scale(BEHAVE-AD)were used to assess the disease.Regression analysis was also used in this study. Resuits The omission rate,mistake rate,reaction time and coefficient of variation of most iterns(visual one objective continuous ear continuous performance test,VOT;visual successive objective objective continuous performance test,VST;ear continuous performance test,ET)of CPT inpatients with AD were abnormal,even after 8 weeks'treatment.These parameters were improved after 8 weeks'treatment although they were higher than those in control group.The parameters before treatment had correlation with the course of disease and the behavior and psychological symptoms of dementia(BPSD). Conclusions　Attention function damage in patients with AD is wide and severe,and the parameters of CPT before treatment are correlated with the course'of disease and BPSD.