ABSTRACT
AIM:
To explore the
safety of
anesthesia for
neonates by studying the effects of
general anesthesia (GA) and spinal-
epidural anesthesia (SA) on the levels of
lactic acid, S100B,
superoxide dismutase (SOD) and malond-ialdehyde ( MDA) in the
umbilical cord blood and placental stereological changes .
METHODS:
The singleton , term preg-nancy of 50
patients for elective
cesarean section were assigned to 2 groupsGA group and SA group , with 25
patients in each group.
Blood pressure (BP) and
heart rate (HR) of the parturient
women were monitored and recorded at 6
time points.The
Apgar score was calculated at 1 min and 5 min after
birth.The gas
analysis of the
umbilical artery blood , S100B
protein concentration,
blood lactic acid, SOD and MDA were also measured .Stereological evaluation of the vascular adaptations in the
human placental villous
capillary was performed .
RESULTS:
BP, HR, Apgar scores, gas
analysis, the
pH value of the
umbilical artery blood , the
serum concentrations of
S 100B protein and the length density of villous capillar-ies had no significant change between the 2 groups (P>0.05).The levels of
blood lactic acid and SOD in GA group were significantly lower than those in SA group (P<0.01).MDA content and volume density of villous
capillaries in GA group were significantly higher than those in SA group ( P<0.01 ) .
CONCLUSION:
General anesthesia for
cesarean section was
safety for
neonates .However, as indicated by the
oxidation index ,
general anesthesia may have some harmful effect on the
neonates by
oxygen free radicals .