ABSTRACT
Objective:
To study the relationship between
plasma level of N-terminal
B-type natriuretic peptide (NT-proBNP) and ventricular diastolic dysfunction in elder hypertensive
patients without target organ damage.
Methods:
A total of 66 relevant
patients treated in our
hospital from 2012-03 to 2014-03 were studied. According to the standard of ventricular diastolic dysfunction, the
patients were divided into 2 groups Study group, n=27
patients with diastolic dysfunction and
Control group, n=39
patients without diastolic dysfunction. The
patients in Study group were further divided into 3 sub-groups based on Doppler
classification of diastolic dysfunctionGrade 1, the
patients with E/A90 ms, n=8. Grade 2, the
patients with E/A>1.5, DT (150-220) ms, IVRT1.5, DT≤150 ms, IVRT NT-proBNP and ventricular diastolic dysfunction.
Results:
Plasma level of NT-proBNP was higher in Study group than that in
Control group. NT-proBNP level in Grade 3-4 sub-group was obviously higher than those in Grade 1 and Grade 2 sub-groups, NT-proBNP level in Grade 2 sub-group was higher than that in Grade 1 sub-group. Pearson correlation
analysis indicated that NT-proBNP level was positively related to systolic
blood pressure, diastolic function and E/E’ (r=0.211, P=0.037, r=0.442, P=0.004 and r=0.556, P=0.000), while negatively related to E’/A’ (r=-0.372, P=0.000).
Conclusion:
The increased
plasma level of NT-proBNP are highly support for ventricular diastolic dysfunction in elder hypertensive
patients without target organ damage, NT-proBNP level is related to ventricular diastolic function.
