ABSTRACT
BACKGROUND:
Artificial valve replacement for valvular
disease has good biocompatibility and
hemodynamic characteristics, but there are stil many factors that
affect its
therapeutic effects.
OBJECTIVE:
To detect the level of
serum Apelin-12 in the
perioperative period of valve replacement in valvular
disease patients with atrial fibrilation.
METHODS:
Sixty-two
patients with
valvular heart disease scheduled for artificial valve replacement were selected, including 30
patients with persistent atrial fibrilation (atrial fibrilation group) and 32
patients with sinus rhythm (sinus rhythm group). There were 33
males and 29
females, with a mean age of (55±11) years. Levels of
serum Apelin-12 and makers related to
inflammation and
oxidative stress were detected in two groups at admission. Furthermore, the sinus rhythm group was sub-divided into postoperative atrial fibrilation (POAF) group (n=8) and non-POAF group (n=24) after valve replacement, and the above-mentioned
indicators were detected and compared between these two subgroups. RESULTS AND
CONCLUSION:
Compared with the sinus rhythm group, the
serum level of
Apelin-12 was significantly lower in the atrial fibrilation group, while the levels of high-
sensitivity C-reactive protein and
interleukin-6 and total
antioxidant capacity were significantly higher in the atrial fibrilation group (P <0.05). Correlation
analysis showed that the
serum level of
Apelin-12 was negatively correlated with high-
sensitivity C-reactive protein level and total
antioxidant capacity (r=-0.265,P=0.045;r=-0.960,P <0.001), but not correlated with the
interleukin-6 level (r=-0.155,P=0.230). Compared with the non-POAF group, the
serum level of
Apelin-12 was significantly lower in the POAF group (P< 0.05), but the left atrial diameter, high-
sensitivity C-reactive protein level were higher in the POAF group (P < 0.05).
Apelin-12 may take part in the occurrence and
maintenance of atrial fibrilation through the
regulation of
inflammations and
oxidative stresses. The testing of
serum Apelin-12 has a certain value in predicting the occurrence of postoperative atrial fibrilation.