Bruton tyrosine kinase inhibitor in B cell malignancies / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
; (12): 504-506, 2013.
Article
在 Zh
| WPRIM
| ID: wpr-474520
Responsible library:
WPRO
ABSTRACT
Bruton tyrosine kinase (BTK) is a non-receptor tyrosine kinase which belongs to the Tec kinase family and plays an important role in B cell receptor signaling.Nowadays,BTK has been a nove] target for treating some B cell malignancies.Recently,some studies have confirmed that BTK inhibitor,PCI-32765 (ibrutinib),can effectively treat chronic lymphocytic leukemia,mantle cell lymphoma and so on.This review will discuss the preclinical and clinical development of this BTK inhibitor in B cell malignancies.